Background: Congenital hearing loss is remarkably heterogeneous, with over 130 deafness genes and thousands of variants, making for innumerable genotype/phenotype combinations.Understanding both the pathophysiology of hearing loss and molecular site of lesion along the auditory pathway permits for significantly individualized counseling.Electrophys
Matthias Helmschrott,1 Rasmus Rivinius,1 Thomas Bruckner,2 Hugo A Katus,1 Andreas O Doesch1 1Department of Cardiology, Angiology, Pneumology, 2Institute for Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany Background: A calcineurin inhibitor (CNI)-based immunosuppression combined with mammalian target of rapamycin inh
Around 257 million people are living with hepatitis B virus (HBV) chronic infection and 71 million with hepatitis C virus (HCV) chronic infection.Both HBV and HCV infections can lead to liver complications such as cirrhosis and hepatocellular carcinoma (HCC).To take care of these chronically infected patients, one strategy is to diagnose the early
Hendra henipavirus (HeV) is an emerging zoonotic bat-borne paramyxovirus that is capable of causing severe public health complications in humans.It promotes both respiratory and neurological disorders in humans as well as in horses.Currently, there are no therapeutics or vaccines available against the deadly HeV.We aimed to design a potent and nove